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  • Writer's picturechadwalkaden

Microdosing Psilocybin and Placebo Effect


The use of psychedelics for therapeutic purposes has gained much popularity in recent years. Among the most commonly used substances is psilocybin, the active ingredient in magic mushrooms. One trend that has emerged is microdosing, which involves taking small doses of psilocybin to improve creativity, productivity, and well-being. However, the effectiveness of microdosing is often challenged by the placebo effect. In this article, we will explore the concept of microdosing psilocybin and the potential impact of the placebo effect on its perceived benefits.

What is Microdosing Psilocybin?

Microdosing psilocybin involves taking small amounts of psilocybin, typically one-tenth to one-twentieth of a standard macro dose, with the intention of improving mood, focus, creativity, and overall well-being. The practice is believed to have originated in Silicon Valley and has since spread across the world. Users of microdosing report a range of benefits, including improved energy, creativity, empathy, and reduced anxiety and depression.

How Does Microdosing Psilocybin Work?

Psilocybin is a powerful psychedelic compound that interacts with the brain's serotonin receptors, leading to altered states of consciousness and a range of psychological and physiological effects. In small doses, it is believed to enhance cognitive function, creativity, and mood. However, the mechanisms by which microdosing psilocybin works are not yet fully understood and require further research.

The Placebo Effect

The placebo effect is a phenomenon in which a patient's belief in a treatment's effectiveness leads to actual improvements in symptoms, despite the treatment having no active ingredients. The placebo effect is a powerful psychological mechanism that has been shown to improve a wide range of conditions, from pain to depression and anxiety.

The Impact of the Placebo Effect on Microdosing Psilocybin

While the benefits of microdosing psilocybin are often reported anecdotally, the placebo effect may play a significant role in these perceived benefits. For example, a study found that the placebo effect accounted for up to 80% of the benefits reported by participants in a microdosing study. The study also found that participants who were told they were receiving microdoses, but were actually receiving a placebo, reported significant improvements in mood and cognitive function.

The Importance of Placebo-Controlled Studies

To fully understand the potential benefits and risks of microdosing psilocybin, more research is needed, particularly placebo-controlled studies that can control for the placebo effect. By controlling for the placebo effect, researchers can accurately measure the actual benefits of microdosing psilocybin and determine whether it is a viable therapeutic option.

Potential Risks of Microdosing Psilocybin

While the risks of microdosing psilocybin are relatively low, they do exist. Some potential risks include:

  • Anxiety and paranoia

  • Increased heart rate and blood pressure

  • Increased risk of accidents and injury

  • Psychological dependence and addiction

It is essential to note that these risks are typically associated with high doses of psilocybin and are unlikely to occur with microdosing. However, caution is always advised when using any psychoactive substance.


Microdosing psilocybin has gained much popularity in recent years, with many people reporting benefits such as improved creativity, productivity, and well-being. However, the placebo effect may play a significant role in these perceived benefits, making it challenging to determine whether microdosing psilocybin is a viable therapeutic option. More research, particularly placebo-controlled studies, is needed to fully understand the potential benefits and risks of microdosing psilocybin

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